EVALUATION OF ANTI-DIABETIC EFFECTS OF POLY-HERBAL PRODUCT ìDIABETIC BALî IN ALLOXAN-INDUCED DIABETIC RABBITS ALAMGEER*, MUHAMMAD NUMAN, SAYED ATIF RAZA, MUHAMMAD NAVEED

The current study was conducted to evaluate the anti-diabetic effect of polyherbal product ìdiabetic balî in normal and alloxan induced diabetic rabbits. Glibenclamide was used as standard drug. Diabetes was induced by single i.v. injection of 150 mg/kg b.w. of alloxan monohydrate in rabbits. ìDiabetic balî (250 and 500 mg/kg) significantly decreased the blood glucose level both in normal and diabetic rabbits in dose dependent manner. In oral glucose tolerance test, ìDiabetic balî demonstrated a significant inhibitory effect on rise of blood glucose level compared to control. ìDiabetic balî showed synergistic anti-hyperglycemic effect with different units of insulin in diabetic rabbits. The ìdiabetic balî decreased the glucose level and prevented the weight loss of diabetic rabbits as compared to control for an extended period of one month. It caused a significant increase (p < 0.001) in the insulin level of treated diabetic rabbits in 30 days study. In addition AST, ALT, ALP, cholesterol, LDLs, VLDLs and triglyceride level were significantly reduced whereas HDLs level was significantly elevated in diabetic rabbits with 500 mg/kg dose. The herbal product did not cause any significant change in CBC as compared to normal control in diabetic rabbits for one month. It is conceivable; therefore, that ìdiabetic balî is effective in diabetes and its associated complications which support its use in folklore.